649 OX40/OX40L and 4-1BB/4-1BBL signaling in cutaneous anti-tumoral immunity

HIV-1 Adenoviral Vector Vaccines Expressing Multi-Trimeric BAFF and 4-1BBL Enhance T Cell Mediated Anti-Viral Immunity

Adenoviral vectored vaccines have shown considerable promise but could be improved by molecular adjuvants. Ligands in the TNF superfamily (TNFSF) are potential adjuvants for adenoviral vector (Ad5) vaccines based on their central role in adaptive immunity. Many TNFSF ligands require aggregation beyond the trimeric state (multi-trimerization) for optimal biological function. Here we describe Ad5...

CD28 Reveals a Role for 4-1BBL in Skin Mice and of Mice Lacking Both 4-1BBL and Analysis of 4-1BB Ligand (4-1BBL)-Deficient

Anti-Leukemia Activity of MS-275 Histone Deacetylase Inhibitor Implicates 4-1BBL/4-1BB Immunomodulatory Functions

Histone deacetylase inhibitors (HDACi) have demonstrated promising therapeutic potential in clinical trials for hematological malignancies. HDACi, such as SAHA/Vorinostat, Trichostatin A, and MS-275 were found to induce apoptosis of leukemic blasts through activation of the death receptor pathway and transcriptional induction of the Tumor Necrosis Factor (TNF)-related pro-apoptotic family membe...

New Insights in Cutaneous Melanoma Immune-Therapy — Tackling Immune-Suppression and Specific Anti- Tumoral Response

Carcinogenicity and Anti-tumoral Effect of Parasites: A Review Study

In endemic areas, some parasitic infections may be related to cancer induction or induction of immune responses against cancer. In some cases, parasites cause disease in their host, and in other cases, they reach a biological balance with them. Parasite invasion of the host depends on some factors such as parasite species, life cycle, enzyme production, and host immunity. The results of various...